Sequence information
Variant position: 153 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 218 The length of the canonical sequence.
Location on the sequence:
EHNTSVVKKIHIEVVDKANR
D MASIVSEIMMYVLIVVLTIW
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EHNTSVVKKIHIEVVDKANRD MASIVSEIMMYVLIVVLTIW
EHNTSVVKKIHIEVVDKANRD MASIVSEIMMYVLIVVLTIW
Chimpanzee EHNTSVVKKIHIEVVDKANRD MASIVSEIMMYVLIVVLTIW
Mouse EHNTSVVKKIHLEVVDKANRD MASIVSEIMMYVLIVVLTIW
Rat EHNTSVVKKIHLEVVDKANRD MASIVSEIMMYVLIVVLTIW
Bovine EHNTSVVKKIHLEVVDKANRD MASIVSEIMMYVLIVVLTIW
Rabbit EHNTSVVKKIHLEVVDKANRD MASIVSEIMMYVLIVVLTIW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
19 – 218
Sodium channel subunit beta-1
Topological domain
19 – 160
Extracellular
Glycosylation
135 – 135
N-linked (GlcNAc...) asparagine
Alternative sequence
150 – 218
ANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE -> GESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVVLGLPGIIIRCVSRGVV. In isoform 2.
Literature citations
Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.
Watanabe H.; Darbar D.; Kaiser D.W.; Jiramongkolchai K.; Chopra S.; Donahue B.S.; Kannankeril P.J.; Roden D.M.;
Circ. Arrhythm. Electrophysiol. 2:268-275(2009)
Cited for: VARIANTS ATFB13 HIS-85 AND ASN-153; CHARACTERIZATION OF VARIANTS ATFB13 HIS-85 AND ASN-153;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.