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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P30556: Variant p.Leu222Val

Type-1 angiotensin II receptor
Gene: AGTR1
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Variant information Variant position: help 222
Type of variant: help LB/B
Residue change: help From Leucine (L) to Valine (V) at position 222 (L222V, p.Leu222Val).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 222
Protein sequence length: help 359
Location on the sequence: help LGFLFPFLIILTSYTLIWKA L KKAYEIQKNKPRNDDIFKII
Residue conservation: help 
Human                         LGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKII

                              LGFLFPFLIILTSYTLIWKTLKRAYEIQKNKPRNDDIFKII

Chimpanzee                    LGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKII

Pig                           LGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKII

Bovine                        LGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKII

Rabbit                        LGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKII

Sheep                         LGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKII

Chicken                       LGFLIPFLIILTSYTLIWKTLKKAYQIQRNKTRNDDIFKMI
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 359 Type-1 angiotensin II receptor
Topological domain 217 – 239 Cytoplasmic
Disulfide bond 18 – 274
Helix 205 – 226



Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS VAL-222 AND HIS-341;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.