Variant position: 134 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GGLMLPLREPVVTLEGHTKR VGIVAWHTTAQNVLLSAGCDN
Mouse GGLVLPLREPVITLEGHTKR VGIVAWHPTAQNVLLSAGCDN
Rat GGLVLPLREPVVTLEGHTKR VGIVAWHPTAQNVLLSAGCDN
Bovine GGLTLPLREPVVTLEGHTKR VGIVAWHPTAQNVLLSAGCDN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.
Moshous D.; Martin E.; Carpentier W.; Lim A.; Callebaut I.; Canioni D.; Hauck F.; Majewski J.; Schwartzentruber J.; Nitschke P.; Sirvent N.; Frange P.; Picard C.; Blanche S.; Revy P.; Fischer A.; Latour S.; Jabado N.; de Villartay J.P.;
J. Allergy Clin. Immunol. 131:1594-1603(2013)
Cited for: VARIANT IMD8 MET-134; CHARACTERIZATION OF VARIANT IMD8 MET-134;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.