Variant position: 32 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 268 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ACASSCGVPSFPPNLSARVV GGEDARPHSWPWQISLQYLKN
Mouse ACASSCGDPTFPPNLSARVV GGEDAVPNSWPWQVSLQYLRD
Rat ACASCCGNPAFPPNLSTRVV GGEDAVPNSWPWQVSLQYLKD
Bovine AYASSCGAPIFQPNLSARVV GGEDAIPHSWPWQISLQYLRD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
30 – 268 Chymotrypsin-C
30 – 267 Peptidase S1
25 – 25 N-linked (GlcNAc...) asparagine
52 – 52 N-linked (GlcNAc...) asparagine
17 – 141
Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.
Beer S.; Zhou J.; Szabo A.; Keiles S.; Chandak G.R.; Witt H.; Sahin-Toth M.;
Cited for: VARIANTS ARG-18; TYR-35 AND SER-227; VARIANTS PCTT ARG-178 AND GLU-250; CHARACTERIZATION OF VARIANTS ARG-18; TYR-35; ARG-48; ARG-61; ARG-220 AND GLN-254; CHARACTERIZATION OF VARIANTS PCTT VAL-32; THR-73; TYR-155; ARG-178; ARG-217; SER-217; ILE-235; 247-LYS--ARG-254 DEL; LEU-249; GLU-250 AND TRP-254;
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