Variant position: 295 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 559 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DIAKTVSPEKLLEKAFAIRL FSRKEIQLLQMANEKALKQKG
Mouse DIAKTVSPEKLLEKAFAIRL FSRKEIQLLQMANEKALRQKG
Bovine DIAKTVSPEKLLEKAFAIRL FSRKEIQLLQMANEKALKQKG
Xenopus laevis DLNKCVTPEKLLEKAFAIRL FSRKEIQLLQMANEKALQQKG
Xenopus tropicalis DLNQCVAPEKLLEKAFAIRL FSRKEIQLLQMANEKALQQKG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 559 TBC1 domain family member 24
293 – 297 Phosphatidylinositol binding
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
Hirosawa M.; Nagase T.; Ishikawa K.; Kikuno R.; Nomura N.; Ohara O.;
DNA Res. 6:329-336(1999)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LEU-295;
Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.
Ishibashi K.; Kanno E.; Itoh T.; Fukuda M.;
Genes Cells 14:41-52(2009)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT LEU-295;
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