Variant position: 629 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 664 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PIQGQQKKPFEEHWRKHTLS YVDVGTGKVTLEYRPVIDKTL
Mouse PIQGQQKKPFGEHWRKHTLS YVDIKTGKVTLEYRPVIDKTL
Rat PIEGQQKKPFAEHWRKHTLS YVDTKTGKVTLDYRPVIDKTL
Pig PIQGQQKKPFQEHWRKHTLS YVDVKTGKVSLEYRPVIDKTL
Bovine PIQGQQKKPFEQHWRKHTLS YVDIKTGKVTLEYRPVIDRTL
Chicken PLQGQQKRPFEEHWRKHTLS YVDVKSGKVTLKYRPVIDRTL
Xenopus tropicalis PIQGQQKKSFSEHWRKHTLS YVD-GKGKVSLEYRPVIDTTL
Zebrafish PLQGQVKKPFEQHWRKHTLS YVDPETGKVTLEYRPVIDSSL
Caenorhabditis elegans PLEGQTKKELKDHWRKHSII RSNIETGEVSLDYRPVIDTTL
Drosophila PLDGQQKKPMDQHWRKHTLS WVCNDNGDITLDYRNVIDTTL
Slime mold ------------NWMKHTLS YLDVNTGKVTLNYRPVVSETL
Baker's yeast ------------HWMKHTLS WQKDVAAPVTLKYRRVIDHTL
Fission yeast ------------NWIKHTLT WQHKTGDPVTLKYRAVTRTTM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
43 – 664 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
615 – 615 N6-succinyllysine
624 – 624 N6-acetyllysine
636 – 636 N6-acetyllysine
647 – 647 N6-acetyllysine
The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase.
Morris A.A.M.; Farnsworth L.; Ackrell B.A.C.; Turnbull D.M.; Birch-MacHin M.A.;
Biochim. Biophys. Acta 1185:125-128(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS PHE-629 AND ILE-657;
Homo sapiens protein coding cDNA.
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.; Ohara O.; Nagase T.; Kikuno R.F.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT PHE-629;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3); VARIANT PHE-629;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.