Variant position: 371 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 906 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLCEPTPQDHIKVTQEQYEL YCEMGSTFQLCKICAENDKDV
Mouse GLCEPTPQDHIKVTQEQYEL YCEMGSTFQLCKICAENDKDV
Fission yeast -------------------- -----SALDMILRCCKSNSHV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 906 E3 ubiquitin-protein ligase CBL
352 – 380 Linker
358 – 906 Required for ubiquitination of SPRED2
357 – 476 Asp/Glu-rich (acidic)
371 – 371 Phosphotyrosine; by INSR
371 – 371 Y -> F. Strongly reduces tyrosine phosphorylation by INSR; when associated with F-700 and F-774.
381 – 381 C -> A. Loss of ubiquitin ligase activity.
365 – 378
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
Fernandes M.S.; Reddy M.M.; Croteau N.J.; Walz C.; Weisbach H.; Podar K.; Band H.; Carroll M.; Reiter A.; Larson R.A.; Salgia R.; Griffin J.D.; Sattler M.;
J. Biol. Chem. 285:32596-32605(2010)
Cited for: VARIANTS ARG-287; SER-LYS-365 INS; HIS-371 AND LEU-499; CHARACTERIZATION OF VARIANTS SER-LYS-365 INS AND HIS-371; PHOSPHORYLATION AT TYR-674; TYR-700 AND TYR-774;
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