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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q15831: Variant p.Asp176Asn

Serine/threonine-protein kinase STK11
Gene: STK11
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Variant information Variant position: help 176 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Aspartate (D) to Asparagine (N) at position 176 (D176N, p.Asp176Asn). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (N) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In PJS; loss of kinase activity, leading to greatly reduced autophosphorylation; fails to phosphorylate PTEN in vitro; no significant effect on nucleocytoplasmic localization. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 176 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 433 The length of the canonical sequence.
Location on the sequence: help YFCQLIDGLEYLHSQGIVHK D IKPGNLLLTTGGTLKISDLG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         YFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLG

Mouse                         YFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLG

Rat                           YFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLG

Chicken                       YFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLG

Xenopus laevis                YFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTDGTLKISDLG

Slime mold                    IFRQLIEACEYIHSQKILHRDIKPDNILFTHANVLKLSDFG
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 430 Serine/threonine-protein kinase STK11
Domain 49 – 309 Protein kinase
Active site 176 – 176 Proton acceptor
Modified residue 189 – 189 Phosphothreonine; by autocatalysis
Mutagenesis 189 – 189 T -> A. Reduced phosphorylation.
Mutagenesis 194 – 194 D -> A. Loss of kinase activity.



Literature citations
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H.; Lin-Marq N.; Buchet-Poyau K.; Reymond A.; Collart M.A.; Picard D.; Antonarakis S.E.;
Hum. Mol. Genet. 14:2209-2219(2005)
Cited for: FUNCTION; INTERACTION WITH PTEN; SUBCELLULAR LOCATION; CHARACTERIZATION OF VARIANT PJS ASN-176; Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H.; Gehrig C.; Nezu J.; Oku A.; Shimane M.; Rossier C.; Guex N.; Blouin J.L.; Scott H.S.; Antonarakis S.E.;
Am. J. Hum. Genet. 63:1641-1650(1998)
Cited for: VARIANTS PJS 50-LEU--ASP-53 DEL; ASN-176 AND CYS-308; CHARACTERIZATION OF VARIANTS PJS PRO-67; ASN-176 AND CYS-308; MUTAGENESIS OF LYS-78;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.