Variant position: 176 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 433 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YFCQLIDGLEYLHSQGIVHK DIKPGNLLLTTGGTLKISDLG
Mouse YFRQLIDGLEYLHSQGIVHK DIKPGNLLLTTNGTLKISDLG
Rat YFRQLIDGLEYLHSQGIVHK DIKPGNLLLTTNGTLKISDLG
Chicken YFCQLIDGLEYLHSQGIVHK DIKPGNLLLTTNGTLKISDLG
Xenopus laevis YFCQLIDGLEYLHSQGIVHK DIKPGNLLLTTDGTLKISDLG
Slime mold IFRQLIEACEYIHSQKILHR DIKPDNILFTHANVLKLSDFG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 430 Serine/threonine-protein kinase STK11
49 – 309 Protein kinase
176 – 176 Proton acceptor
189 – 189 Phosphothreonine; by autocatalysis
189 – 189 T -> A. Reduced phosphorylation.
194 – 194 D -> A. Loss of kinase activity.
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H.; Lin-Marq N.; Buchet-Poyau K.; Reymond A.; Collart M.A.; Picard D.; Antonarakis S.E.;
Hum. Mol. Genet. 14:2209-2219(2005)
Cited for: FUNCTION; INTERACTION WITH PTEN; SUBCELLULAR LOCATION; CHARACTERIZATION OF VARIANT PJS ASN-176;
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H.; Gehrig C.; Nezu J.; Oku A.; Shimane M.; Rossier C.; Guex N.; Blouin J.L.; Scott H.S.; Antonarakis S.E.;
Am. J. Hum. Genet. 63:1641-1650(1998)
Cited for: VARIANTS PJS 50-LEU--ASP-53 DEL; ASN-176 AND CYS-308; CHARACTERIZATION OF VARIANTS PJS PRO-67; ASN-176 AND CYS-308; MUTAGENESIS OF LYS-78;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.