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UniProtKB/Swiss-Prot P07478: Variant p.Asp153His

Trypsin-2
Gene: PRSS2
Variant information

Variant position:  153
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Aspartate (D) to Histidine (H) at position 153 (D153H, p.Asp153His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (D) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism:  His-153 variation is a common polymorphism in African populations with a minor allele frequency of 9.2%, it eliminates sulfation at Tyr-154, with no consequences on digestive physiology.
Additional information on the polymorphism described.

Variant description:  Abolishes tyrosine sulfation.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  153
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  247
The length of the canonical sequence.

Location on the sequence:   PAAGTESLISGWGNTLSSGA  D YPDELQCLDAPVLSQAECEA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         PAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEA

                              AAPGTQCLISGWGNTLSSGTNYPELLQCLDAPILTQAQCEA

Mouse                         APAGTQCLISGWGNTLSNGVNNPDLLQCVDAPVLPQADCEA

Rat                           APAGTQCLISGWGNTLSSGVNEPDLLQCLDAPLLPQADCEA

Bovine                        ASAGTECLISGWGNTLSSGVNYPDLLQCLVAPLLSHADCEA

Chicken                       VTAGTTCLISGWGNTLSSGSLYPDVLQCLNAPVLSSSQCSS

Xenopus laevis                ASAGTNCLISGWGNTLSSGTNYPDLLQCLNAPILTDSQCSN

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 24 – 247 Trypsin-2
Domain 24 – 244 Peptidase S1
Modified residue 154 – 154 Sulfotyrosine
Disulfide bond 30 – 160


Literature citations

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).
Ronai Z.; Witt H.; Rickards O.; Destro-Bisol G.; Bradbury A.R.; Sahin-Toth M.;
Biochem. J. 418:155-161(2009)
Cited for: VARIANT HIS-153; CHARACTERIZATION OF VARIANT HIS-153;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.