Variant position: 153 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 247 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAAGTESLISGWGNTLSSGA DYPDELQCLDAPVLSQAECEA
Mouse APAGTQCLISGWGNTLSNGV NNPDLLQCVDAPVLPQADCEA
Rat APAGTQCLISGWGNTLSSGV NEPDLLQCLDAPLLPQADCEA
Bovine ASAGTECLISGWGNTLSSGV NYPDLLQCLVAPLLSHADCEA
Chicken VTAGTTCLISGWGNTLSSGS LYPDVLQCLNAPVLSSSQCSS
Xenopus laevis ASAGTNCLISGWGNTLSSGT NYPDLLQCLNAPILTDSQCSN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).
Ronai Z.; Witt H.; Rickards O.; Destro-Bisol G.; Bradbury A.R.; Sahin-Toth M.;
Biochem. J. 418:155-161(2009)
Cited for: VARIANT HIS-153; CHARACTERIZATION OF VARIANT HIS-153;
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