Sequence information
Variant position: 102 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 629 The length of the canonical sequence.
Location on the sequence:
KKEKKVLNHGYDDDNHDYIV
R SGERWLERYEIDSLIGKGSF
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKEKKVLNHGYDDDNHDYIVR SGERWLERYEIDSLIGKGSF
Mouse KKEKKVLNHGYDDDNHDYIVR SGERWLERYEIDSLIGKGSF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 629
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Modified residue
92 – 92
Phosphotyrosine
Modified residue
111 – 111
Phosphotyrosine
Literature citations
A form of the metabolic syndrome associated with mutations in DYRK1B.
Keramati A.R.; Fathzadeh M.; Go G.W.; Singh R.; Choi M.; Faramarzi S.; Mane S.; Kasaei M.; Sarajzadeh-Fard K.; Hwa J.; Kidd K.K.; Babaee Bigi M.A.; Malekzadeh R.; Hosseinian A.; Babaei M.; Lifton R.P.; Mani A.;
N. Engl. J. Med. 370:1909-1919(2014)
Cited for: FUNCTION; VARIANTS AOMS3 PRO-90 AND CYS-102; CHARACTERIZATION OF VARIANTS AOMS3 PRO-90 AND CYS-102;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.