Variant position: 361 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 602 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKTQILVGVNKDEGTAFLVY GAPGFSKDNNSIITRKEFQEG
Mouse KKAQILVGVNKDEGTAFLVY GAPGFSKDNDSLITRKEFQEG
Bovine KKTQILVGVNKDEGTAFLVY GAPGFSKDNNSIITRKEFQEG
Rabbit KKTQILVGVNKDEGTAFLVY GAPGFSKDNTSIITRKEFQEG
Cat KKTQILVGVNKDEGTAFLVY GAPGFSKDNDSIITRKEFQEG
Horse KRTQILVGVNKDEGTAFLVY GAPGFSKDNNSIITRKEFQEG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
29 – 602 Cholinesterase
353 – 353 Charge relay system
369 – 369 N-linked (GlcNAc...) (complex) asparagine
359 – 361
Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.
Mikami L.R.; Wieseler S.; Souza R.L.; Schopfer L.M.; Nachon F.; Lockridge O.; Chautard-Freire-Maia E.A.;
Pharmacogenet. Genomics 18:213-218(2008)
Cited for: VARIANT BCHED CYS-361; VARIANTS ARG-40; MET-322 AND TRP-498; CHARACTERIZATION OF VARIANT BCHED CYS-361; CHARACTERIZATION OF VARIANTS ARG-40; MET-322 AND TRP-498;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.