Variant position: 115 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 652 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVGSAVWQLIASFLRLPISG THCIVGSTIGFSLVAIGTKGV
Mouse MVGSAVWQLIASFLRLPISG THCIVGSTIGFSLVAIGPKGV
Rat MVGSAVWQLIASFLRLPISG THCIVGSTIGFSLVAIGPKGV
Bovine MVGSAVWQLIASFLRFPISG THCIVGATIGFSLVAIGTQGV
Cat MVGSAVWQLIASFLRLPISG THCIVGSTIGFSLVAIGTQGV
Xenopus laevis MVGSAVWQLIASFLKLPVSG THCIVGATIGFSLVAVGAHSV
Xenopus tropicalis MVGSAVWQLIASFLRLPISG THCIVGATIGFSLVAIGTHGV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 652 Sodium-dependent phosphate transporter 2
110 – 130 Helical
Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in Japan.
Yamada M.; Tanaka M.; Takagi M.; Kobayashi S.; Taguchi Y.; Takashima S.; Tanaka K.; Touge T.; Hatsuta H.; Murayama S.; Hayashi Y.; Kaneko M.; Ishiura H.; Mitsui J.; Atsuta N.; Sobue G.; Shimozawa N.; Inuzuka T.; Tsuji S.; Hozumi I.;
Cited for: VARIANTS IBGC1 VAL-51; HIS-71; MET-115 AND ARG-637;
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