Variant position: 443 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1024 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTGLLCKYTAQRFKPKYKFF HKSFQEYTAGRRLSSLLTSHE
Mouse TIGLLCKYTAQRLKPTYKFF HKSFQEYTAGRRLSSLLTSKE
Rat RTGLLCKYTAQRLRPTYKFF HKSFQEYTAGRRLSSLLKSRE
Bovine TTGLLCKYTAQRFKPKYKFF HQSFQEYTAGRRLSSLLTSGE
Xenopus tropicalis NIGLLNKYTAQRRKAVYRYF HTTFQEYIAGRRLSQLLSSED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1024 NLR family CARD domain-containing protein 4
163 – 476 NACHT
356 – 463 Winged-helix domain (WHD)
89 – 753 Missing. In isoform 2.
93 – 1024 Missing. In isoform 4.
157 – 1024 Missing. In isoform 3.
An inherited mutation in NLRC4 causes autoinflammation in human and mice.
Kitamura A.; Sasaki Y.; Abe T.; Kano H.; Yasutomo K.;
J. Exp. Med. 211:2385-2396(2014)
Cited for: INVOLVEMENT IN FCAS4; VARIANT FCAS4 PRO-443; CHARACTERIZATION OF VARIANT FCAS4 PRO-443; SUBUNIT;
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