Sequence information
Variant position: 9 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 52 The length of the canonical sequence.
Location on the sequence:
MEKVQYLT
R SAIRRASTIEMPQQARQKLQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEKVQYLTR SAIRRASTIEMPQQARQKLQ
MDKVQYLTR SAIRRASTIEMPQQARQNLQ
Mouse MEKVQYLTR SAIRRASTIEMPQQARQNLQ
Rat MEKVQYLTR SAIRRASTIEMPQQARQNLQ
Pig MDKVQYLTR SAIRRASTIEMPQQARQNLQ
Bovine MDKVQYLTR SAIRRASTIEMPQQARQNLQ
Rabbit MEKVQYLTR SAIRRASTIEMPQQARQNLQ
Chicken MEKVQYITR SALRRASTLEVNPQARQRLQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 52
Cardiac phospholamban
Topological domain
1 – 31
Cytoplasmic
Modified residue
1 – 1
N-acetylmethionine
Modified residue
16 – 16
Phosphoserine; by PKA and DMPK
Modified residue
17 – 17
Phosphothreonine; by CaMK2
Mutagenesis
13 – 13
R -> A. Abolishes phosphorylation by PKA.
Mutagenesis
14 – 14
R -> A. Abolishes phosphorylation by PKA.
Mutagenesis
16 – 16
S -> A. Abolishes phosphorylation by PKA.
Mutagenesis
17 – 17
T -> A. No effect on phosphorylation by PKA.
Helix
4 – 14
Literature citations
Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.
Ceholski D.K.; Trieber C.A.; Holmes C.F.; Young H.S.;
J. Biol. Chem. 287:26596-26605(2012)
Cited for: FUNCTION; CHARACTERIZATION OF VARIANTS CMD1P HIS-9; LEU-9; CYS-9 AND ARG-14 DEL; PHOSPHORYLATION AT SER-16; MUTAGENESIS OF ARG-13; ARG-14; SER-16 AND THR-17;
Mutations in the human phospholamban gene in patients with heart failure.
Medeiros A.; Biagi D.G.; Sobreira T.J.; de Oliveira P.S.; Negrao C.E.; Mansur A.J.; Krieger J.E.; Brum P.C.; Pereira A.C.;
Am. Heart J. 162:1088-1095(2011)
Cited for: VARIANTS CMD1P HIS-9 AND LEU-9;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.