Variant position: 762 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 836 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QSNSRVFESHSFNSILNQPT RYQQIMKRLIKRYVLKAQVDK
Mouse QSNSRVFESHSFNSILNQPT RYQQIMKRLIKRYVLKAQVDK
Rat QSNSRVFESHSFNSILNQPT RYQQIMKRLIKRYVLKAQVDK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 836 Short transient receptor potential channel 3
659 – 836 Cytoplasmic
762 – 785
Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?
Fogel B.L.; Hanson S.M.; Becker E.B.;
Mov. Disord. 30:284-286(2015)
Cited for: INVOLVEMENT IN SCA41; VARIANT SCA41 HIS-762; CHARACTERIZATION OF VARIANT SCA41 HIS-762;
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