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UniProtKB/Swiss-Prot P01584: Variant p.Glu141Asn

Interleukin-1 beta
Gene: IL1B
Variant information

Variant position:  141
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Glutamate (E) to Asparagine (N) at position 141 (E141N, p.Glu141Asn).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (E) to medium size and polar (N)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  0
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  Requires 2 nucleotide substitutions.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  141
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  269
The length of the canonical sequence.

Location on the sequence:   SLNCTLRDSQQKSLVMSGPY  E LKALHLQGQDMEQQVVFSMS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMS

                              SVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMS

Rhesus macaque                SLHCTLRDAQLKSLVMSGPYELKALHLQGQDLEQQVVFSMS

Mouse                         QLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMS

Rat                           QLHCRLRDEQQKCLVLSDPCELKALHLNGQNISQQVVFSMS

Pig                           SMECKLQDKDHKSLVLAGPHMLKALHLLTGDLKREVVFCMS

Bovine                        SIKCKLQDREQKSLVLASPCVLKALHLLSQEMNREVVFCMS

Rabbit                        SLHCRLQDAQQKSLVLSGTYELKALHLNAENLNQQVVFSMS

Goat                          SVKCKLQDREQKSLVLDSPCVLKALHLLSQEMSREVVFCMS

Sheep                         SVKCKLQDREQKSLVLDSPCVLKALHLPSQEMSREVVFCMS

Cat                           SQDYTFRDISQKSLVLSGSYELRALHLNGQNMNQQVVFRMS

Horse                         SVNCRLRDIYHKSLVLSGACELQAVHLNGENTNQQVVFCMS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 117 – 269 Interleukin-1 beta
Beta strand 141 – 145


Literature citations

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1.
Van Damme J.; De Ley M.; Opdenakker G.; Billiau A.; De Somer P.; Van Beeumen J.;
Nature 314:266-268(1985)
Cited for: PROTEIN SEQUENCE OF 117-155; VARIANT ASN-141; FUNCTION; TISSUE SPECIFICITY;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.