Variant position: 173 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 582 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSENSLTSLPDSLDNLKKLR MLDLRHNKLREIPSVVYRLDS
Mouse LSENSLTSLPDSLDNLKKLR MLDLRHNKLREIPSVVYRLDS
Rat LSENSLTSLPDSLDNLKKLR MLDLRHNKLREIPSVVYRLDS
Bovine LSENSLTSLPDSLDNLKKLR MLDLRHNKLREIPSVVYRLDS
Chicken LSENSLTSLPDSLDNLKKLR MLDLRHNKLREIPSVVYRLTS
Xenopus laevis LSENSLTSLPDSLDNLKKLC MLDLRHNKLREIPPVVYRLSS
Zebrafish LSENSLTSLPDSLDNLKKLR MLDLRHNKLREIPAVVYRVSS
Caenorhabditis elegans LSENALTSLPDSLASLESLE TLDLRHNKLTEVPSVIYKIGS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 582 Leucine-rich repeat protein SHOC-2
170 – 191 LRR 4
A Novel SHOC2 Variant in Rasopathy.
Hannig V.; Jeoung M.; Jang E.R.; Phillips J.A. III; Galperin E.;
Hum. Mutat. 35:1290-1294(2014)
Cited for: VARIANT NSLH1 ILE-173; CHARACTERIZATION OF VARIANT NSLH1 ILE-173; FUNCTION; INTERACTION WITH MRAS AND RAF1 AND PHOSPHATASE 1C; SUBCELLULAR LOCATION;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.