Variant position: 1020 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1363 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EAEDLWLSPLTMEDLVCYSF QVARGMEFLASRKCIHRDLAA
Mouse EAEDLWLSPLTMEDLVCYSF QVARGMEFLASRKCIHRDLAA
Rat EAEDLWLSPLTMEDLVCYSF QVARGMEFLASRKCIHRDLAA
Zebrafish TVDDLWKTPLTIEDLICYSF QVARGMEFLASRKCIHRDLAA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 1363 Vascular endothelial growth factor receptor 3
797 – 1363 Cytoplasmic
845 – 1173 Protein kinase
1037 – 1037 Proton acceptor
766 – 1298 Missing. In isoform 3.
A novel VEGFR3 mutation causes Milroy disease.
Butler M.G.; Dagenais S.L.; Rockson S.G.; Glover T.W.;
Am. J. Med. Genet. A 143A:1212-1217(2007)
Cited for: VARIANT LMPH1A LEU-1020;
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