Variant position: 310 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 548 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TVSETANEPP--QDEGNSFNSP RNLAMEATYINHNFSQQCLRM-
Mouse TVSETANEPP--QDEGNSFNSP RNLAMEATYINHNFSQQCL
Rat TVSETANEPP--QDEGNSFNSP RNLAMEATYINHNFSQQCL
Bovine TVSETANEPP--QDEGNSFNSP RNLAMEATYINHNFSQQCL
Xenopus laevis TVSETANEPP--QDEVNSLNSP RNLAMEATYINHNFSQQCL
Xenopus tropicalis TVSETANEPP--QDDVNSLNSP RNLAMEATYINHNFSQQCL
Zebrafish TVSETANEPP--QDEGSSLNSP RNLAMEATYINHNFSQQCL
Caenorhabditis elegans TVSETSAEPP--SFDGNGINNA KDLATEAFYINQNFRRQVV
Slime mold TVNENLTAHH--QDDKDPINTT SSLSQEATQVNLNYWQQVL
Fission yeast TVNENAYDSPMDADNREGVNSP GALSVEATYINQNFCVQAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 548 Eukaryotic translation initiation factor 3 subunit D
Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
Cromer M.K.; Choi M.; Nelson-Williams C.; Fonseca A.L.; Kunstman J.W.; Korah R.M.; Overton J.D.; Mane S.; Kenney B.; Malchoff C.D.; Stalberg P.; Akerstroem G.; Westin G.; Hellman P.; Carling T.; Bjoerklund P.; Lifton R.P.;
Proc. Natl. Acad. Sci. U.S.A. 112:4062-4067(2015)
Cited for: VARIANT CYS-310;
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