Sequence information
Variant position: 200 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 918 The length of the canonical sequence.
Location on the sequence:
TSCTVDYSTVYFVNIEVWVE
A ENALGKVTSDHINFDPVYKV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TSCTVDYSTVYFVNIEVWVEA ENALGKVTSDHINFDPVYKV
Mouse -SCMVSYMPTYYVNIEVWVEA ENALGKVSSESINFDPVDKV
Rat SSCMMGYTPIYFVNIEVWVEA ENALGNVSSEPINFDPVDKV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
23 – 918
Interleukin-6 receptor subunit beta
Topological domain
23 – 619
Extracellular
Domain
125 – 216
Fibronectin type-III 1
Mutagenesis
189 – 189
V -> G. Does not induce ligand-independent activation.
Mutagenesis
190 – 190
Y -> G. Does not induce ligand-independent activation.
Mutagenesis
215 – 215
D -> G. Induces ligand-independent activation.
Beta strand
194 – 202
Literature citations
Low incidence of IL6ST (gp130) mutations in exon 6 in lung cancer of a Chinese cohort.
Sun L.; Sui L.; Cong X.; Ma K.; Ma X.; Huang Y.; Fan C.; Fu X.; Ma K.;
Cancer Genet. 207:291-298(2014)
Cited for: VARIANT GLY-200;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.