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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P22466: Variant p.Ala39Glu

Galanin peptides
Gene: GAL
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Variant information Variant position: help 39 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Alanine (A) to Glutamate (E) at position 39 (A39E, p.Ala39Glu). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and acidic (E) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In ETL8; decreased affinity for GALR2; but no effect on affinity for GALR1 and GALR3; decreased activity in GALR2-mediated signaling; dominant-negative that inhibits GALR1-mediated signaling. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 39 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 123 The length of the canonical sequence.
Location on the sequence: help SASAGLWSPAKEKRGWTLNS A GYLLGPHAVGNHRSFSDKNG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         SASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNG

Mouse                         SATLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHG

Rat                           SATLGLGMPTKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHG

Pig                           SATLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKYG

Bovine                        SATLGLGSPVKEKRGWTLNSAGYLLGPHALDSHRSFQDKHG

Sheep                         --------------GWTLNSAGYLLGPHAIDNHRSFHDKHG

Chicken                       --------------GWTLNSAGYLLGPHAVDNHRSFNDKHG

Zebrafish                     TETLGMVIAAKEKRGWTLNSAGYLLGPHAIDSHRSLSDKHG

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Peptide 33 – 62 Galanin
Helix 36 – 43



Literature citations
Galanin pathogenic mutations in temporal lobe epilepsy.
Guipponi M.; Chentouf A.; Webling K.E.; Freimann K.; Crespel A.; Nobile C.; Lemke J.R.; Hansen J.; Dorn T.; Lesca G.; Ryvlin P.; Hirsch E.; Rudolf G.; Rosenberg D.S.; Weber Y.; Becker F.; Helbig I.; Muhle H.; Salzmann A.; Chaouch M.; Oubaiche M.L.; Ziglio S.; Gehrig C.; Santoni F.; Pizzato M.; Langel U.; Antonarakis S.E.;
Hum. Mol. Genet. 24:3082-3091(2015)
Cited for: FUNCTION; INVOLVEMENT IN ETL8; VARIANT ETL8 GLU-39; CHARACTERIZATION OF VARIANT ETL8 GLU-39;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.