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UniProtKB/Swiss-Prot Q9NUQ7: Variant p.Tyr290His

Ufm1-specific protease 2
Gene: UFSP2
Chromosomal location: 4q35.1
Variant information

Variant position:  290
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Disease [Disclaimer]
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Tyrosine (Y) to Histidine (H) at position 290 (Y290H, p.Tyr290His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and aromatic (Y) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Involvement in disease:  Beukes familial hip dysplasia (BFHD) [MIM:142669]: A severe progressive degenerative osteoarthritis of the hip joint with underlying dysplasia confined to that region. Affected individuals are of normal stature and have no associated health problems. {ECO:0000269|PubMed:26428751}. Note=The disease is caused by mutations affecting the gene represented in this entry.
The name and a short description of the disease associated with the variant. For more information about the disease, the user can refer to OMIM, following the link provided after the disease acronym.

Variant description:  In BFHD; loss of protease activity toward the C-terminal of UFM1.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  290
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  469
The length of the canonical sequence.

Location on the sequence:   PPNMETGMIYVVQGIYGYHH  Y MQDRIDDNGWGCAYRSLQTI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         PPNMETGMIYVVQGIYGYHHYMQDRIDDNGWGCAYRSLQTI

Mouse                         PPNIEGSMICVVQGTYAYHHYMQDRIDDNGWGCAYRSLQTI

Rat                           PPNIEGSMICMVQGTYAYHHYMQNRVDDNGWGCAYRSLQTV

Chicken                       SPGPESGVVYLVHGTYSYHHYMQDRTDDSGWGCAYRSLQTI

Xenopus laevis                TPPLEGATVSLVQGLYSYHHYMQDRMDDNGWGCAYRSLQTI

Zebrafish                     PPNIEDAKLYLVQGVYSYHHYMQDRVDDDGWGCAYRSLQTI

Drosophila                    PSGVVDGKEYLVNGNYHYYHYLQQQVQDKGWGCAYRSLQTI

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 469 Ufm1-specific protease 2
Active site 302 – 302
Mutagenesis 302 – 302 C -> S. Catalytically inactive.


Literature citations

Identification of a mutation in the ubiquitin-fold modifier 1-specific peptidase 2 gene, UFSP2, in an extended South African family with Beukes hip dysplasia.
Watson C.M.; Crinnion L.A.; Gleghorn L.; Newman W.G.; Ramesar R.; Beighton P.; Wallis G.A.;
S. Afr. Med. J. 105:558-563(2015)
Cited for: INVOLVEMENT IN BFHD; VARIANT BFHD HIS-290; CHARACTERIZATION OF VARIANT BFHD HIS-290;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.