Variant position: 321 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 777 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YCQASFPGANIIGNKMSAIS VHGVSTSGGQMYHYDMNTA-SL
Mouse YCQASFSGTNIIGNKMSAIS VHGVSTSGGQMYHYDMNTA-S
Rat YCQASFSGTNIIGNKMSAIS VHGVSTSGGQMYHYDMNTA-S
Pig YCQASFSGANIIGGKMSAIS VHGVSTSGGQLYHYDMNTAAS
Rabbit YCQASFSGANIIGNKISAIS VHGVSTSGGQMYHYDMNAQ--
Xenopus laevis YCVGNFSGSGLFGNKSSAIS VHGVSTSGGQMYHYDLNTA-T
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 777 Glucocorticoid receptor
1 – 420 Modulating
1 – 335 Missing. In isoform Alpha-D3.
1 – 330 Missing. In isoform Alpha-D2.
313 – 338 Missing. In isoform 10.
316 – 316 M -> I. Abolishes expression of D-type isoforms; when associated with I-331 and I-336.
331 – 331 M -> I. Abolishes expression of D-type isoforms; when associated with I-316 and I-336.
336 – 336 M -> I. Abolishes expression of D-type isoforms; when associated with I-316 and I-331.
Novel hyperactive glucocorticoid receptor isoform identified within a human population.
Tung K.; Baker A.C.; Amini A.; Green T.L.; Chew V.W.; Lim D.; Nguyen S.T.; Yee K.S.; Cho K.; Greenhalgh D.G.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA); VARIANTS ASP-72; ALA-321 AND SER-766; CHARACTERIZATION OF VARIANTS ASP-72; ALA-321 AND SER-766;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.