Variant position: 155 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 806 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Mouse LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Rat LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Pig LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Bovine LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Xenopus laevis LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Xenopus tropicalis LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Zebrafish LKPYFLEAYRPIRKGDIFLV RGGMRAVEFKVVETDPSPYCI
Drosophila LKPYFLEAYRPIHMGDNFIV RAAMRPIEFKVVLTDPEPYCI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 806 Transitional endoplasmic reticulum ATPase
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
Tresse E.; Salomons F.A.; Vesa J.; Bott L.C.; Kimonis V.; Yao T.P.; Dantuma N.P.; Taylor J.P.;
Cited for: CHARACTERIZATION OF VARIANTS IBMPFD1 HIS-155; SER-155 AND GLU-232; MUTAGENESIS OF GLU-305 AND GLU-578; FUNCTION;
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