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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9BWF2: Variant p.Arg18Cys

E3 ubiquitin-protein ligase TRAIP
Gene: TRAIP
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Variant information Variant position: help 18 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Arginine (R) to Cysteine (C) at position 18 (R18C, p.Arg18Cys). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (C) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In SCKL9; abolished localization to the nucleolus. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 18 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 469 The length of the canonical sequence.
Location on the sequence: help MPIRALCTICSDFFDHS R DVAAIHCGHTFHLQCLIQWF The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWF

Mouse                         MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWF

Xenopus laevis                MPIRAYCTICSDFFDNARDVAAITCGHTFHQECLLQWF
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 469 E3 ubiquitin-protein ligase TRAIP
Zinc finger 7 – 50 RING-type
Mutagenesis 7 – 7 C -> A. Abolished accumulation in nucleolus.
Mutagenesis 25 – 25 C -> A. Abolished ability to regulate nuclear envelope breakdown to anaphase.



Literature citations
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.
Harley M.E.; Murina O.; Leitch A.; Higgs M.R.; Bicknell L.S.; Yigit G.; Blackford A.N.; Zlatanou A.; Mackenzie K.J.; Reddy K.; Halachev M.; McGlasson S.; Reijns M.A.; Fluteau A.; Martin C.A.; Sabbioneda S.; Elcioglu N.H.; Altmueller J.; Thiele H.; Greenhalgh L.; Chessa L.; Maghnie M.; Salim M.; Bober M.B.; Nuernberg P.; Jackson S.P.; Hurles M.E.; Wollnik B.; Stewart G.S.; Jackson A.P.;
Nat. Genet. 48:36-43(2016)
Cited for: INVOLVEMENT IN SCKL9; VARIANT SCKL9 CYS-18; FUNCTION; SUBCELLULAR LOCATION; TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
Hoffmann S.; Smedegaard S.; Nakamura K.; Mortuza G.B.; Raschle M.; Ibanez de Opakua A.; Oka Y.; Feng Y.; Blanco F.J.; Mann M.; Montoya G.; Groth A.; Bekker-Jensen S.; Mailand N.;
J. Cell Biol. 212:63-75(2016)
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 459-469 IN COMPLEX WITH PCNA; FUNCTION; SUBCELLULAR LOCATION; INTERACTION WITH PCNA; MUTAGENESIS OF PHE-466; CHARACTERIZATION OF VARIANT SCKL9 CYS-18;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.