Variant position: 131 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 339 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KLLQGGIETGSITEMFGEFR TGKTQICHTLAVTCQLPIDRG
Mouse KLLQGGIETGSITEMFGEFR TGKTQICHTLAVTCQLPIDRG
Bovine KLLQGGIETGSITEMFGEFR TGKTQICHTLAVTCQLPIDRG
Rabbit KLLQGGIETGSITEMFGEFR TGKTQICHTLAVTCQLPIDRG
Chicken KLLQGGIETGSITELFGEFR TGKTQLCHTLAVTCQLPIDRG
Drosophila KLLGGGIETGSITEIFGEFR CGKTQLCHTLAVTCQLPISQK
Baker's yeast TLLGGGVETGSITELFGEFR TGKSQLCHTLAVTCQIPLDIG
Fission yeast TLLQGGVETGSITELFGEFR TGKSQICHTLAVTCQLPIDMG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 339 DNA repair protein RAD51 homolog 1
127 – 134 ATP
77 – 173 Missing. In isoform 2.
A dominant mutation in human RAD51 reveals its function in DNA interstrand crosslink repair independent of homologous recombination.
Wang A.T.; Kim T.; Wagner J.E.; Conti B.A.; Lach F.P.; Huang A.L.; Molina H.; Sanborn E.M.; Zierhut H.; Cornes B.K.; Abhyankar A.; Sougnez C.; Gabriel S.B.; Auerbach A.D.; Kowalczykowski S.C.; Smogorzewska A.;
Mol. Cell 59:478-490(2015)
Cited for: FUNCTION; INVOLVEMENT IN FANCR; VARIANT FANCR PRO-131; CHARACTERIZATION OF VARIANT FANCR PRO-131;
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