Variant position: 196 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1278 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GELSSSEPS-TPAQTPLAAPI IPTPV--LTSPGAVPPLPSPSKE
Mouse GELSSSEPS-TPAQTPLAAPI IPTPA--LTSPGAAPPLPSP
Rat GELSSSEPS-TPAQTPLAAPI IPTPA--LTSPGAAPPLPSP
Chicken GEMSSSEPS-TPAQTPLVAPV IPSPS--LTSPVAPM-VPSP
Xenopus laevis GEISSSEPS-TPAQTPLAAPI IPSPSSAITSPVAPLPGPGP
Drosophila GFLEILKPQFTPSQ-PLRSPS FTMPS--NSGAEDKVALLEA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1278 Dynactin subunit 1
100 – 223 Disordered
179 – 179 Phosphoserine; by PLK1
212 – 212 Phosphoserine; by CDK1
179 – 179 S -> A. Non-phosphorylatable by PLK1. Decreased nuclear envelope localization. No loss of microtubule-binding. No effect on its interaction with CLIP1.
179 – 179 S -> D. No loss of localization to nuclear envelope. Decrease in microtubule-binding. No effect on its interaction with CLIP1.
212 – 212 S -> A. No effect on its interaction with CLIP1 and PLK1.
The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis.
Muench C.; Meyer R.; Linke P.; Meyer T.; Ludolph A.C.; Haas J.; Hemmer B.;
Acta Neurol. Scand. 116:231-234(2007)
Cited for: VARIANTS VAL-196; GLN-495 AND ILE-1249;
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