Variant position: 670 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1400 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VGPTNVSLTVTNMPPGKHFR VDGTSVLRGFSFMEPVLIAVQ
Mouse VGTTNISLVITNMPAGKHFR VEGISVQEGFSFVEPVLTSIK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 1400 Macrophage-stimulating protein receptor
310 – 1400 Macrophage-stimulating protein receptor beta chain
25 – 957 Extracellular
569 – 671 IPT/TIG 1
654 – 654 N-linked (GlcNAc...) asparagine
496 – 1400 Missing. In isoform RON-1.
648 – 1400 Missing. In isoform RON-2 and isoform RON-4.
Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.
Dai W.; Zheng H.; Cheung A.K.; Tang C.S.; Ko J.M.; Wong B.W.; Leong M.M.; Sham P.C.; Cheung F.; Kwong D.L.; Ngan R.K.; Ng W.T.; Yau C.C.; Pan J.; Peng X.; Tung S.; Zhang Z.; Ji M.; Chiang A.K.; Lee A.W.; Lee V.H.; Lam K.O.; Au K.H.; Cheng H.C.; Yiu H.H.; Lung M.L.;
Proc. Natl. Acad. Sci. U.S.A. 113:3317-3322(2016)
Cited for: VARIANTS NPCA3 HIS-306; THR-327; GLY-670 AND THR-973; INVOLVEMENT IN NPCA3;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.