Variant position: 153 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 846 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VIKAARSQGVDCLVAPYEAD AQLAYLNKAGIVQAIITEDSD
Mouse VIKAARALGVDCLVAPYEAD AQLAYLNKAGIVQAVITEDSD
Xenopus laevis VIKAARSEGVDYIVAPYEAD SQLAYLNKNDFAEAIITEDSD
Zebrafish VIRAARTRGVDCVVAPYEAD AQLAFLNKSDIAQAVITEDSD
Drosophila LIRECRSRNVDCIVAPYEAD AQMAWLNRADVAQYIITEDSD
Slime mold LIKELRALKVEYLVAPYEAD AQLTYLSITGQVDAIITEDSD
Baker's yeast IICYCKLNGIRYIVAPFEAD SQMVYLEQKNIVQGIISEDSD
Fission yeast LIIALREHGIESIVAPYEAD AQLVYLEKENIIDGIITEDSD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 846 Exonuclease 1
129 – 387 Interaction with MSH3
138 – 229 I-domain
150 – 150 Magnesium 1
152 – 152 Magnesium 1
171 – 171 Magnesium 2
173 – 173 Magnesium 2
173 – 173 D -> A. Abrogates double-stranded DNA exonuclease activity and endonuclease activity against 5'-overhanging flap structures. No effect on DNA-binding to 5'-overhanging flap structures.
151 – 160
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.
Hansen M.F.; Johansen J.; Bjoernevoll I.; Sylvander A.E.; Steinsbekk K.S.; Saetrom P.; Sandvik A.K.; Drabloes F.; Sjursen W.;
Fam. Cancer 14:437-448(2015)
Cited for: VARIANT VAL-153;
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