Variant position: 262 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 365 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FFGDDDVFIACGPEKFRYAQ DDFSLDENECRVMKGNPSATA
Mouse FFGDDDVFIACGPEKFRYAQ DDFSLDENECRVMKGNPSAAA
Rat FFGDDDVFIACGPEKFRYAQ DDFSLDENECRVMKGNPSATA
Slime mold II-DGEYYVCAGGETL---- ---------------NPLDFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 365 Neuronal migration protein doublecortin
180 – 263 Doublecortin 2
265 – 265 Phosphoserine; by CK2
A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.
Tsai M.H.; Kuo P.W.; Myers C.T.; Li S.W.; Lin W.C.; Fu T.Y.; Chang H.Y.; Mefford H.C.; Chang Y.C.; Tsai J.W.;
Eur. J. Paediatr. Neurol. 20:788-794(2016)
Cited for: VARIANT LISX1 GLY-262; CHARACTERIZATION OF VARIANT LISX1 GLY-262; SUBUNIT;
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