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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04792: Variant p.Lys141Gln

Heat shock protein beta-1
Gene: HSPB1
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Variant information Variant position: help 141 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Lysine (K) to Glutamine (Q) at position 141 (K141Q, p.Lys141Gln). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (K) to medium size and polar (Q) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In HMND3; decreased thermal stability; changed protein structure; no effect on homooligomerization; changed heterooligomerization with HSPB6; slightly decreased function in chaperone-mediated protein folding. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 141 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 205 The length of the canonical sequence.
Location on the sequence: help TGKHEERQDEHGYISRCFTR K YTLPPGVDPTQVSSSLSPEG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEG

                              TGKHEERQDEHGYISRRLTPKYTLPPGVDPTLVSSSLSPEG

Mouse                         TGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEG

Rat                           TGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEG

Pig                           TGKHEERQDEHGFISRCFTRKYTLPPGVDPTQVSSSLSPEG

Bovine                        TGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEG

Chicken                       TGKHEEKQDEHGFISRCFTRKYTLPPGVEATAVRSSLSPDG

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 205 Heat shock protein beta-1
Domain 76 – 184 sHSP
Region 70 – 205 Interaction with TGFB1I1
Modified residue 123 – 123 N6-acetyllysine
Beta strand 136 – 143



Literature citations
A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.
Ikeda Y.; Abe A.; Ishida C.; Takahashi K.; Hayasaka K.; Yamada M.;
J. Neurol. Sci. 277:9-12(2009)
Cited for: VARIANT HMND3 GLN-141; Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.
Nefedova V.V.; Datskevich P.N.; Sudnitsyna M.V.; Strelkov S.V.; Gusev N.B.;
Biochimie 95:1582-1592(2013)
Cited for: CHARACTERIZATION OF VARIANTS HMND3 GLY-140 AND GLN-141;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.