Variant position: 190 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 205 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PKLATQSNEITIPVTFESRA QLGGPEAAKSDETAAK
Mouse PKAVTQSAEITIPVTFEARA QIGGPEAGKSEQSGAK
Rat PKAVTQSAEITIPVTFEARA QIGGPE---SEQSGAK
Pig PKPATQSAEITIPVTFEARA QLGGTEAGKSEKPGTK
Bovine PKSATQSAEITIPVTFQARA QLGGPEAGKSEQPENK
Chicken PKPAIQSSEITIPVTVEAK- ---------KEEPAKK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 205 Heat shock protein beta-1
70 – 205 Interaction with TGFB1I1
174 – 174 Phosphothreonine
176 – 176 Phosphoserine
199 – 199 Phosphoserine
Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.
Capponi S.; Geuens T.; Geroldi A.; Origone P.; Verdiani S.; Cichero E.; Adriaenssens E.; De Winter V.; Bandettini di Poggio M.; Barberis M.; Chio A.; Fossa P.; Mandich P.; Bellone E.; Timmerman V.;
Hum. Mutat. 37:1202-1208(2016)
Cited for: VARIANT HIS-190;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.