Variant position: 584 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 696 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FFRKDFMLLSNDEICPQLYA RISPTLTSHSKNSTGLAETGT
Mouse FFRKDFMLLSNEEICPQLYA RISPTLTSHSKNSTGLAETGT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 696 SLIT and NTRK-like protein 1
18 – 622 Extracellular
Slitrk missense mutations associated with neuropsychiatric disorders distinctively impair Slitrk trafficking and synapse formation.
Kang H.; Han K.A.; Won S.Y.; Kim H.M.; Lee Y.H.; Ko J.; Um J.W.;
Front. Mol. Neurosci. 9:104-104(2016)
Cited for: FUNCTION; MUTAGENESIS OF VAL-85; CHARACTERIZATION OF VARIANTS ILE-400 AND SER-418; CHARACTERIZATION OF VARIANTS TTM LYS-584 AND GLY-593;
SLITRK1 mutations in trichotillomania.
Zuchner S.; Cuccaro M.L.; Tran-Viet K.N.; Cope H.; Krishnan R.R.; Pericak-Vance M.A.; Wright H.H.; Ashley-Koch A.;
Mol. Psychiatry 11:887-889(2006)
Cited for: VARIANTS TTM LYS-584 AND GLY-593;
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