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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q6QNK2: Variant p.Phe110Leu

Adhesion G-protein coupled receptor D1
Gene: ADGRD1
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Variant information Variant position: help 110
Type of variant: help LB/B
Residue change: help From Phenylalanine (F) to Leucine (L) at position 110 (F110L, p.Phe110Leu).
Physico-chemical properties: help Change from large size and aromatic (F) to medium size and hydrophobic (L)
BLOSUM score: help 0
Variant description: help Reduces cell membrane location; decreases G-protein coupled receptor activity.
Other resources: help


Sequence information Variant position: help 110
Protein sequence length: help 874
Location on the sequence: help NSSCISKPEQCGPEGVTFSF F WKTQGEQSRPIPSAYGGQVI
Residue conservation: help
Human                         NSSCISKPEQCGPEGVTFSFFWKTQGEQSRPIPSAYGGQVI

Mouse                         KSSCISNPAQCGPEGVTFSFFWKTQGDQTRPAPYAYGGQVV

Bovine                        KTSCISNPAQCGPEGVSFSFFWKTQGEQSTSIPSAYGGQVI

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 26 – 874 Adhesion G-protein coupled receptor D1
Topological domain 26 – 570 Extracellular
Domain 79 – 276 Pentraxin (PTX)
Glycosylation 90 – 90 N-linked (GlcNAc...) asparagine
Alternative sequence 1 – 481 Missing. In isoform 3.
Alternative sequence 1 – 314 Missing. In isoform 2.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.