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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P62873: Variant p.Asp118Gly

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Gene: GNB1
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Variant information Variant position: help 118 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Aspartate (D) to Glycine (G) at position 118 (D118G, p.Asp118Gly). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and acidic (D) to glycine (G) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In MRD42; decreases receptor-driven G protein activation; no effect on protein abundance; no effect on complex formation with gamma subunit; no effect on trimer formation with alpha and gamma subunits. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 118 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 340 The length of the canonical sequence.
Location on the sequence: help SWVMTCAYAPSGNYVACGGL D NICSIYNLKTREGNVRVSRE The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 340 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Repeat 95 – 125 WD 2
Beta strand 117 – 119



Literature citations
Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability.
Steinruecke S.; Lohmann K.; Domingo A.; Rolfs A.; Baeumer T.; Spiegler J.; Hartmann C.; Muenchau A.;
Neurol. Genet. 2:E106-E106(2016)
Cited for: VARIANT MRD42 GLY-118; Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.
Lohmann K.; Masuho I.; Patil D.N.; Baumann H.; Hebert E.; Steinruecke S.; Trujillano D.; Skamangas N.K.; Dobricic V.; Huening I.; Gillessen-Kaesbach G.; Westenberger A.; Savic-Pavicevic D.; Muenchau A.; Oprea G.; Klein C.; Rolfs A.; Martemyanov K.A.;
Hum. Mol. Genet. 26:1078-1086(2017)
Cited for: VARIANTS MRD42 PHE-30; GLY-52; VAL-64; ARG-91; THR-92; SER-94; LEU-96; THR-106; GLY-118 AND GLN-337; CHARACTERIZATION OF VARIANTS MRD42 PHE-30; GLY-52; VAL-64; ARG-91; THR-92; SER-94; LEU-96; THR-106; GLY-118 AND GLN-337;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.