Sequence information
Variant position: 1001 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2005 The length of the canonical sequence.
Location on the sequence:
LLLSSFSSDNLAATDDDNEM
N NLQIAVGRMQKGIDFVKRKI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LLLSSFSSDNLAATDDDNEMN NLQIAVGRMQKGIDFVKRKI
Mouse LLLSSFSSDNLAATDDDNEMN NLQIAVGRMQKGIDFVKRKI
Rat LLLSSFSSDNLAATDDDNEMN NLQIAVGRMQKGIDFVKRKI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 2005
Sodium channel protein type 2 subunit alpha
Topological domain
983 – 1209
Cytoplasmic
Repeat
741 – 1013
II
Literature citations
A novel SCN2A mutation in family with benign familial infantile seizures.
Striano P.; Bordo L.; Lispi M.L.; Specchio N.; Minetti C.; Vigevano F.; Zara F.;
Epilepsia 47:218-220(2006)
Cited for: VARIANT BFIS3 LYS-1001;
Genetic testing in benign familial epilepsies of the first year of life: clinical and diagnostic significance.
Zara F.; Specchio N.; Striano P.; Robbiano A.; Gennaro E.; Paravidino R.; Vanni N.; Beccaria F.; Capovilla G.; Bianchi A.; Caffi L.; Cardilli V.; Darra F.; Bernardina B.D.; Fusco L.; Gaggero R.; Giordano L.; Guerrini R.; Incorpora G.; Mastrangelo M.; Spaccini L.; Laverda A.M.; Vecchi M.; Vanadia F.; Veggiotti P.; Viri M.; Occhi G.; Budetta M.; Taglialatela M.; Coviello D.A.; Vigevano F.; Minetti C.;
Epilepsia 54:425-436(2013)
Cited for: VARIANTS BFIS3 GLN-223; LYS-1001; GLN-1319 AND ASN-1641;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.