Variant position: 147 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 847 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RYPEDKITPENLPQILLQLK RRRTEEGPTLSYGRDGRSATR
Mouse RYPEDKITPENLPQILLQLK RRRTEEGPTLSYGRDGRSATR
Rat RYPEDKITPENLPQILLQLK RRRTEEGPTLSYGRDGRSATR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 847 Matrin-3
150 – 150 Phosphothreonine
157 – 157 Phosphoserine
158 – 158 Phosphotyrosine
164 – 164 Phosphoserine
132 – 132 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
146 – 146 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
1 – 304 MSKSFQQSSLSRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNK -> MLGAQWRRNQPSRAAE. In isoform 2.
A novel Arg147Trp MATR3 missense mutation in a slowly progressive ALS Italian patient.
Origone P.; Verdiani S.; Bandettini Di Poggio M.; Zuccarino R.; Vignolo M.; Caponnetto C.; Mandich P.;
Amyotroph. Lateral Scler. Frontotemporal Degener. 16:530-531(2015)
Cited for: VARIANT ALS21 TRP-147;
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