Sequence information
Variant position: 119 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 175 The length of the canonical sequence.
Location on the sequence:
MEFDTRERWENPLMGWASTA
D PLSNMVLTFSTKEDAVSFAE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEFDTRERWENPLMGWASTAD PLSNMVLTFSTKEDAVSFAE
Gorilla MEFDTRERWENPLMGWASTAD PLSNMVLTFSTKEDAVSFAE
Chimpanzee MEFDTRERWENPLMGWASTAD PLSNMVLTXSTKEDAVSFAE
Mouse MEFDTRERWENPLMGWASTAD PLSNMVLTFSAKEDAIAFAE
Rat MEFDTRERWENPLMGWASTAD PLSNMVLTFSAKEDAVAFAE
Bovine MEFDTRERWENPLMGWASTAD PLSNLVLTFSTKEDAVAFAE
Drosophila IEFDNRERWENPLMGWASSGD PLSNMNVQFGSPEEAITFCE
Slime mold IELPFNPKWNDRLMGWWASKD TLNQLNLRFNSETDAVAYCK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
43 – 175
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Literature citations
NDUFS4 mutations cause Leigh syndrome with predominant brainstem involvement.
Leshinsky-Silver E.; Lebre A.S.; Minai L.; Saada A.; Steffann J.; Cohen S.; Roetig A.; Munnich A.; Lev D.; Lerman-Sagie T.;
Mol. Genet. Metab. 97:185-189(2009)
Cited for: VARIANT MC1DN1 HIS-119;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.