Variant position: 158 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 219 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ATGLMIGCLVYPDGWDSSEV RRMCGEQTGKYTLGHCTIRWA
Mouse ATGLMIGCLVYPDGWDSSEV RRMCGEQTGKYTLGHCTIRWA
Rat ATGLMIGCLVYPDGWDSSEV RRMCGEQTGKYTLGHCTIRWA
Chicken ATGLMIGCLIYPDGWDSSEV KRMCGDKTDKYTLGACTVRWA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 219 LHFPL tetraspan subfamily member 5 protein
150 – 178 Extracellular
Clinical and molecular delineation of dysequilibrium syndrome type 2 and profound sensorineural hearing loss in an inbred Arab family.
Komara M.; John A.; Suleiman J.; Ali B.R.; Al-Gazali L.;
Am. J. Med. Genet. A 170A:540-543(2016)
Cited for: VARIANT DFNB67 TRP-158;
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