Variant position: 263 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 473 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TEALAPLRALQYLRLNDNPW VCDCRARPLWAWLQKFRGSSS
Mouse AEVLMPLRSLQYLRLNDNPW VCDCRARPLWAWLQKFRGSSS
Rat AEVLVPLRSLQYLRLNDNPW VCDCRARPLWAWLQKFRGSSS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 447 Reticulon-4 receptor
250 – 273 LRR 9
260 – 310 LRRCT
277 – 277 K -> A. No effect on interaction with MAG.
277 – 277 K -> D. Decreases interaction with MAG; when associated with D-279.
279 – 279 R -> A. Mildly decreases interaction with MAG.
279 – 279 R -> D. Decreases interaction with MAG; when associated with D-277.
279 – 279 R -> E. Impaired ganglioside binding.
Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.
Budel S.; Padukkavidana T.; Liu B.P.; Feng Z.; Hu F.; Johnson S.; Lauren J.; Park J.H.; McGee A.W.; Liao J.; Stillman A.; Kim J.E.; Yang B.Z.; Sodi S.; Gelernter J.; Zhao H.; Hisama F.; Arnsten A.F.; Strittmatter S.M.;
J. Neurosci. 28:13161-13172(2008)
Cited for: FUNCTION; INTERACTION WITH MAG; RTN4; OMG; NGFR AND LINGO1; INVOLVEMENT IN SCZD; VARIANTS MET-53; HIS-68; SER-141; HIS-227; MET-263; SER-314; LEU-329 AND MET-363; VARIANTS SCZD TRP-119; HIS-196; CYS-227; GLN-377; TRP-377 AND TRP-399; CHARACTERIZATION OF VARIANTS SCZD TRP-119; HIS-196; GLN-377 AND TRP-377;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.