Variant position: 281 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 886 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VFNGFLDFILRPDDPRAQTL RRLFVFKLIPMLNPDGVVRGH
Mouse VFNGFLDFILRPDDPRAQTL RRLFVFKLIPMLNPDGVVRGH
Rat VFNGFLDFILRPDDPRAQTL RRLFVFKLIPMLNPDGVVRGH
Bovine VFNGFLDFILRPDDPRAQTL RRLFVFKLIPMLNPDGVVRGH
Xenopus tropicalis VFNGFLEFILRQDDPRAQML RRMFVFKLIPMLNPDGVVRGH
Zebrafish VFNGFLNFILSQEDPRAQTL RRMFVFKLIPMLNPDGVVRGH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 886 Cytosolic carboxypeptidase-like protein 5
Establishing the involvement of the novel gene AGBL5 in retinitis pigmentosa by whole genome sequencing.
Branham K.; Matsui H.; Biswas P.; Guru A.A.; Hicks M.; Suk J.J.; Li H.; Jakubosky D.; Long T.; Telenti A.; Nariai N.; Heckenlively J.R.; Frazer K.A.; Sieving P.A.; Ayyagari R.;
Physiol. Genomics 48:922-927(2016)
Cited for: VARIANTS RP75 CYS-281 AND 487-ARG--VAL-886 DEL;
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