Variant position: 2500 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2530 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FVQRHMPTIRCQPSGHWEEP QITCTDPTTYKRRLQKRSSRH
Mouse FVQRHVPTIRCQPSGHWEEP RITCTDPNTYKHRLQKRSMRP
Rat FVQRHVPTIRCQPSADWEEP RITCTDPNTYKHRLQKRTMRP
Bovine FIQGHVPTIRCQPSGHWEEP RITCTDPATYKRRLQKRSSRP
Chicken YIQRHVPTIRCQPNGHWEEP RISCTNPSSYQRRLYKRSPRS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage.
Dudhia J.; Davidson C.M.; Wells T.M.; Vynios D.H.; Hardingham T.E.; Bayliss M.T.;
Biochem. J. 313:933-940(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1893-2530 (ISOFORM 2); VARIANTS VAL-2079 AND ARG-2500;
A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain.
Baldwin C.T.; Reginato A.M.; Prockop D.J.;
J. Biol. Chem. 264:15747-15750(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2051-2530 (ISOFORM 1); VARIANTS VAL-2079 AND ARG-2500;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.