Variant position: 64 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1017 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NSSLSPPPAKLSVVSFAPSS NGTPEVETTSLNDVTLSLLPS
Mouse NSSLLSPSAESSLVSLIPYS NGTPDAASEVLSTL-------
Rat NSSLLSPSAESSLVSLVPYS NGTPDAASEVLSTL-------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
38 – 1017 Adhesion G-protein coupled receptor G2
38 – 627 Extracellular
44 – 44 N-linked (GlcNAc...) asparagine
51 – 66 Missing. In isoform 3 and isoform 10.
52 – 101 AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> EVETTSLNDVTLSLLPSNET. In isoform 7.
52 – 101 AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> DVTLSLLPSNET. In isoform 8.
52 – 75 Missing. In isoform 5.
Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.
Harripaul R.; Vasli N.; Mikhailov A.; Rafiq M.A.; Mittal K.; Windpassinger C.; Sheikh T.I.; Noor A.; Mahmood H.; Downey S.; Johnson M.; Vleuten K.; Bell L.; Ilyas M.; Khan F.S.; Khan V.; Moradi M.; Ayaz M.; Naeem F.; Heidari A.; Ahmed I.; Ghadami S.; Agha Z.; Zeinali S.; Qamar R.; Mozhdehipanah H.; John P.; Mir A.; Ansar M.; French L.; Ayub M.; Vincent J.B.;
Mol. Psychiatry 23:973-984(2018)
Cited for: VARIANT SER-64;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.