Variant position: 296 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 501 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WQLLSIIVLMGGQQLSGVNA IYYYADQIYLSAGVPEEHVQY
Mouse WQLISMIVLMAGQQLSGVNA IYYYADQIYLSAGVKSDDVQY
Rat WQLISTIVLMAGQQLSGVNA IYYYADQIYLSAGVKSNDVQY
Bovine WQVISIIVLMAGQQLSGVNA IYYYADQIYLSAGVNEDDVQY
Rabbit WQLISVVPLMW-QQLSGVNA IYYY-DQIYLSP--LDTDTQY
Sheep WQVISIIVLMAGQQLSGVNA IYYYADQIYLSAGVKEDDVQY
Horse WQVISIIILMGGQQLSGVNA IYYYADQIYLSAGVKDQDVQY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 501 Solute carrier family 2, facilitated glucose transporter member 5
278 – 298 Helical; Name=7
296 – 298 Fructose binding
288 – 288 Fructose
192 – 501 WPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ -> EFRTSREHPHPFTTTLGPLLVFQSHHHRTGLSADWSLLTGWMSLGGPSCPEPT. In isoform 2.
Reassessment of GLUT7 and GLUT9 as putative fructose and glucose transporters.
Ebert K.; Ludwig M.; Geillinger K.E.; Schoberth G.C.; Essenwanger J.; Stolz J.; Daniel H.; Witt H.;
J. Membr. Biol. 250:171-182(2017)
Cited for: FUNCTION; CATALYTIC ACTIVITY; BIOPHYSICOCHEMICAL PROPERTIES; SUBCELLULAR LOCATION; VARIANT VAL-296; CHARACTERIZATION OF VARIANT VAL-296;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.