Sequence information
Variant position: 422 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 662 The length of the canonical sequence.
Location on the sequence:
RARTGLVSDMGIFDQIMSTG
G GGHVQLLKQAGAFLTYSSFC
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RARTGLVSDMGIFDQIMSTGG GGHVQLLKQAGAFLTYSSFC
Mouse RARSDLISERGFFDKVMSTGG GGHLDLLKQAGAFLTYSSLC
Rat RARSDLISERGFFDKAMSTGG GGHLDLLKQAGAFLTYCSLC
Pig RARNGLVSDLGIFDQVVSTGG GGHVELLRRAAALLTYSSFC
Bovine RARTGLVSDSGVFDQVVSTGG GGHVELLQRAGAFLTYSSFC
Rabbit RARNGLVSDFGIFDQIMSTGG GGHVQLLQQAGAFLTYRSFC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 662
Polyunsaturated fatty acid lipoxygenase ALOX15
Domain
115 – 662
Lipoxygenase
Mutagenesis
418 – 418
M -> V. Catalyzes 15- and 12-lipoxygenation.
Literature citations
Functional characterization of genetic enzyme variations in human lipoxygenases.
Horn T.; Reddy Kakularam K.; Anton M.; Richter C.; Reddanna P.; Kuhn H.;
Redox Biol. 1:566-577(2013)
Cited for: CATALYTIC ACTIVITY; FUNCTION; BIOPHYSICOCHEMICAL PROPERTIES; VARIANTS GLN-205; TRP-402; ARG-422; GLU-422; MET-560 AND SER-617; CHARACTERIZATION OF VARIANTS GLN-205; TRP-402; ARG-422; GLU-422; MET-560 AND SER-617;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.