Variant position: 720 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 805 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VEKAIRMSRSRINDAFRLND NSLEFLGIQPTLGPPNQPPVS
Mouse VEDAIRMSRGRINDVFGLND NSLEFLGIHPTLEPPYQPPVT
Rat VEEAIRMSRGRINDIFGLND NSLEFLGIYPTLKPPYEPPVT
Bovine VENAIRLSRDRINDVFQLDD NSLEFLGIQPTLGPPYEPPVT
Cat VEEAIRMSRSRINDAFRLDD NSLEFLGIQPTLSPPYQPPVT
Baker's yeast REDALMVHRSRMICTGGKKL EHSINKKLTSPKKSLLDSPHD
Fission yeast RLDALNRHKQRNICVGGV-- ---------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 805 Angiotensin-converting enzyme 2
18 – 740 Extracellular
719 – 724
Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome.
Shikov A.E.; Barbitoff Y.A.; Glotov A.S.; Danilova M.M.; Tonyan Z.N.; Nasykhova Y.A.; Mikhailova A.A.; Bespalova O.N.; Kalinin R.S.; Mirzorustamova A.M.; Kogan I.Y.; Baranov V.S.; Chernov A.N.; Pavlovich D.M.; Azarenko S.V.; Fedyakov M.A.; Tsay V.V.; Eismont Y.A.; Romanova O.V.; Hobotnikov D.N.; Vologzhanin D.A.; Mosenko S.V.; Ponomareva T.A.; Talts Y.A.; Anisenkova A.U.; Lisovets D.G.; Sarana A.M.; Urazov S.P.; Scherbak S.G.; Glotov O.S.;
Front. Genet. 11:551220-551220(2020)
Cited for: VARIANT ASP-720;
Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations.
Li Q.; Cao Z.; Rahman P.;
Mol. Genet. Genomic Med. 0:0-0(2020)
Cited for: VARIANTS ARG-26; VAL-468; SER-638 AND ASP-720;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.