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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q06520: Variant p.Pro76Thr

Sulfotransferase 2A1
Gene: SULT2A1
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Variant information Variant position: help 76
Type of variant: help LB/B
Residue change: help From Proline (P) to Threonine (T) at position 76 (P76T, p.Pro76Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to medium size and polar (T)
BLOSUM score: help -1
Variant description: help Decreases of the sulfotransferase activity toward DHEA; decreases of the sulfotransferase activity toward pregnenolone.
Other resources: help


Sequence information Variant position: help 76
Protein sequence length: help 285
Location on the sequence: help LMHSKGDAKWIQSVPIWERS P WVESEIGYTALSETESPRLF
Residue conservation: help 
Human                         LMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLF

Mouse                         LIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLI

Rat                           LIQTKGDPKWIQSVTIWDRSPWIETDLGYDMLIKKKGPRLI
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 285 Sulfotransferase 2A1



Literature citations
Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.
Abunnaja M.S.; Alherz F.A.; El Daibani A.A.; Bairam A.F.; Rasool M.I.; Gohal S.A.; Kurogi K.; Suiko M.; Sakakibara Y.; Liu M.C.;
Biochem. Cell Biol. 96:655-662(2018)
Cited for: CHARACTERIZATION OF VARIANTS GLU-44; THR-76; LYS-147; LYS-148; PRO-246; LEU-258 AND GLU-262; CATALYTIC ACTIVITY; BIOPHYSICOCHEMICAL PROPERTIES; FUNCTION;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.