Variant position: 548 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1527 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AAYLHTTTTFTWMCSPFLVT LITLWVYVYVDPNNVLDAEKA
Mouse GAYLQAISTFIWICTPFLVT LITLGVYVYVDESNVLDAEKA
Rat GAYLQAISTFIWVCTPFMVT LITLGVYVCVDKNNVLDAEKA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1527 ATP-binding cassette sub-family C member 3
534 – 554 Helical; Name=10
311 – 594 ABC transmembrane type-1 1
511 – 1527 Missing. In isoform 3.
547 – 572 TLITLWVYVYVDPNNVLDAEKAFVSV -> RLGTGLGPCLQGSGCPGMARAHWTLP. In isoform 5.
Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).
Lee Y.M.; Cui Y.; Koenig J.; Risch A.; Jaeger B.; Drings P.; Bartsch H.; Keppler D.; Nies A.T.;
Cited for: FUNCTION; CATALYTIC ACTIVITY; VARIANTS GLN-548 AND HIS-1297; CHARACTERIZATION OF VARIANT HIS-1297; SUBCELLULAR LOCATION; BIOPHYSICOCHEMICAL PROPERTIES;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.