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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O00743: Variant p.Gly189Arg

Serine/threonine-protein phosphatase 6 catalytic subunit
Gene: PPP6C
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Variant information Variant position: help 189 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glycine (G) to Arginine (R) at position 189 (G189R, p.Gly189Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help Found in patients with melanomas; decreased protein phosphatase activity, leading to increased phosphorylation of STING1. Any additional useful information about the variant.


Sequence information Variant position: help 189 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 305 The length of the canonical sequence.
Location on the sequence: help DIKTLDQIRTIERNQEIPHK G AFCDLVWSDPEDVDTWAISP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         DIKTLDQIRTIERNQEIPHKGAFCDLVWSDP-EDVDTWAISP

Mouse                         DIKTLDQIRTIERNQEIPHKGAFCDLVWSDP-EDVDTWAIS

Rat                           DIKTLDQIRTIERNQEIPHKGAFCDLVWSDP-EDVDTWAIS

Caenorhabditis elegans        DIRTIDSLMLLDRAQEVPNKGPLCDIMWSDPDDDVEDWVIS

Drosophila                    EIITLDQIRTIDRNGEIPYKGAFCDLVWSDP-EDMEYWGQS

Slime mold                    KVRTLDQIRIISRNLEIPHEGPFCDLMWSDP-EDIEQWQPS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 305 Serine/threonine-protein phosphatase 6 catalytic subunit
Chain 2 – 305 Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed



Literature citations
PPP6C negatively regulates STING-dependent innate immune responses.
Ni G.; Ma Z.; Wong J.P.; Zhang Z.; Cousins E.; Major M.B.; Damania B.;
MBio 11:0-0(2020)
Cited for: FUNCTION; VARIANTS TYR-55; TYR-114 AND ARG-189; CHARACTERIZATION OF VARIANTS TYR-55; TYR-114 AND ARG-189;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.