Issue 14 September 2001 ( PDF )

Princess Bala's sting

by Vivienne Baillie Gerritsen

‘Zookeepers are trained to inspect and monitor service portal perimeters before opening and while inserting their arms. Always use long forceps to change food dishes or remove debris.’ Against which animal could these warnings be for? A ferocious feline? A vicious viper? A ruthless rodent? Nope. An ant. Paraponera clavata, otherwise known as the bullet ant. Bullet ants are jet black and about 25mm in length. They are amongst the most primitive of the ant species: their social organisation is envied by no other species of ant and their queen is barely larger than her subjects. Princess Bala in the famous movie Antz was named so after the Spanish ‘bala’ meaning ‘bullet’. And the bullet ant is also known as the bala ant for the same reason.

One of the first descriptions ever of a bullet ant’s sting on a human, was made in the 1920s by the Belgian natural historian Joseph Charles Bequaert (1886-1982). Such a sting is extremely painful and often compared with the pain caused by a bullet shot – hence the name bullet ant. For those who have not been shot but rather stung by a wasp, the pain caused by the sting of a bullet ant is 30 times worse… The ants do this by way of a retractable syringe-like lance on their abdominal tip from which they inject a potent nerve toxin into prey or enemies. The debilitating pain lasts for 3 to 5 hours and only lessens the following day. Trembling, perspiration, nausea and paralysis of the injured member are also frequently part of the bargain, and multiple stings can lead to death.

[ Paraponera clavata ]

Paraponera clavata

Courtesy of Chris Schmidt

The nastiness of the sting is due to a very small neurotoxin peptide: poneratoxin. Poneratoxin was first described in the early 1990s when an effort was being made to find natural substances which could lead to the development of insecticides and new types of muscle-relaxing compounds. Poneratoxin is the major active neurotoxic compound in ant venom. It causes slow and long-lasting contractions of mammalian smooth muscles, blocks synaptic transmission by changing the kinetics of the voltage-dependent sodium channels and affects the excitability of insect axons. At low concentrations, these effects are reversible.

One venom reservoir holds 1μg of poneratoxin; for a small insect this is enough to block transmission irreversibly if the venom is injected straight into the creature’s central nervous system. For a vertebrate, it has been estimated that 30 bullet ant stings per kg is enough to kill. It is believed that poneratoxin accounts for the paralysis, death and uncontrollable trembling of a subject but the severe and long-drawn-out pain is probably the achievement of another neuroactive fraction of the ant’s venom.

More research will undoubtedly lead to the development of new drugs and insecticides. The Indians of Central America, however, did not wait for the era of genetic engineering to address their ails and pains. Bullet ant stings have been used for centuries to treat rheumatism and similar afflictions besides being administered during tribal manhood rituals. The ant itself has very strong mandibles that can serve as a suture. It is left to bite close to the wound; its head is then twisted off and the pincers hold the wound tightly closed. And the ant’s saliva causes the skin to swell thus sealing the opening hermetically.

1. Piek T., Duval A., Hue B., Karst H., Lapied B., Mantel P., Nakajima T., Pelhate M., Schmidt J.O.
Poneratoxin, a novel peptide neurotoxin from the venom of the ant, Paraponera clavata
Comp. Biochem. Physiol. 99C:487-495(1991)
PMID: 1685425

2. Piek T., Hue B., Mantel P., Nakajima T., Schmidt O.
Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (f.)
Comp. Biochem. Physiol. 99C:481-486(1991)
PMID: 1685424

3. Morgan R.C.
Giant tropical bullet ant, Paraponera clavata, natural history and captive management
Swiss-Prot cross references
Poneratoxin, Paraponera clavata (Bullet ant): P41736
Need to reference this article ? Please use this link:


I was stung (bitten) 5 times on my calf by a Bala Ant at La Selva in Costa Rica in January of 1981 (or 82) If I had not brought my bee-sting kit with me even though I was told there were no bees at the time, I would have died of anaphylactic shock. I was delirious for close to 12 hours and the pain lasted for days. My leg was swollen twice its normal size. The La Selva staff presented me with a Bala in a Bottle when I left.

Posted by Sally Blanchard on Saturday 18 November 2006 2:48 CET

Is there a good reference for the source of information on the use of the ant for suturing wounds ?

Posted by Shyamal on Friday 2 February 2007 4:54 CET

I'm glad the person above got stung by those ants. I think that is hilarious that they gave you one in a bottle after you left. Was that to get some kind of revenge?

Posted by Jim Boxton on Saturday 5 May 2007 22:37 CET

Uhhhhhh I needed this paragraoh so i could do my homework :)

Posted by Ariana Bice on Thursday 20 January 2011 13:32 CET

Post a comment


Please refrain from off-topic banter and personal attacks. Your comment may be edited or removed at the discretion of Protein Spotlight editors. Our goal is not to stifle debate but to keep it relevant.

No HTML tags allowed. If you wish to specify a link to another site, write it in full without any kind of formating and it shall appear live automagically.


Interested in writing for Protein Spotlight? Do you have an idea for an article? Describe it in two or three sentences and use our Contact page to send it to us.

Visitors since September 14th, 2010:

vBulletin stats